Actinogen Medical is an ASX-listed Australian biotech developing its lead asset Xanamem, a specific and selective 11beta-HSD1 inhibitor designed to treat cognitive impairment (CI), which occurs in chronic neurodegenerative and neuropsychiatric diseases.
The unmet need in chronic neurocognitive disorders is tremendous due to the limited effectiveness of available treatment options. The Phase IIb portion of the XanaMIA trial will be key for validating the encouraging Xanamem data shown to date.
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Dr Steven Gourlay
CEO and MD
Michael Roberts
Head of investor relations
% | 1M | 3M | 12M |
---|---|---|---|
Actual | (4.2) | (25.8) | 29.5 |
Relative | (5.6) | (28.4) | 12.6 |
52 week high/low | A$0.1/A$0.0 |
Actinogen Medical’s lead asset, Xanamem, is a once-daily oral selective 11beta-HSD1 inhibitor, designed to cross the blood-brain barrier and target excess brain cortisol, which has been associated with cognitive impairment (CI) in chronic brain conditions such as Alzheimer’s disease (AD), the company’s lead indication. Positive results in healthy adults demonstrated the drug’s initial efficacy, while an analysis of biomarker-positive (pTau-181) patients using plasma samples from the previous XanADu study in mild AD also showed clinical activity using the CDR-SB scale. Actinogen dosed the first patient in its Phase IIb XanaMIA trial in patients with biomarker-confirmed early AD in Q224, and plans to report interim data in mid CY25. Actinogen is also evaluating Xanamem as a treatment for depression symptoms in major depressive disorder (MDD), following positive efficacy signals shown in the Phase IIa XanaCIDD study.
Y/E Jun | Revenue (A$m) | EBITDA (A$m) | PBT (A$m) | EPS (fd) (c) | P/E (x) | P/CF (x) |
---|---|---|---|---|---|---|
2022A | 3.6 | (9.1) | (7.9) | (0.460) | N/A | N/A |
2023A | 4.9 | (10.6) | (8.9) | (0.494) | N/A | N/A |
2024E | 7.9 | (15.0) | (14.2) | (0.629) | N/A | N/A |
2025E | 7.6 | (14.1) | (14.0) | (0.516) | N/A | N/A |