Henderson Opportunities Trust — Taking AIM at the opportunity

Henderson Opportunities Trust (LSE: HOT)

Last close As at 21/12/2024

GBP2.32

−1.50 (−0.64%)

Market capitalisation

GBP92m

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Research: Investment Companies

Henderson Opportunities Trust — Taking AIM at the opportunity

With a focus on long-term growth, Henderson Opportunities Trust (HOT) seeks investment opportunities across the breadth of the UK market. This includes a strong bias towards smaller and earlier-stage companies with significant potential to become tomorrow’s leading British businesses. HOT’s managers, James Henderson and Laura Foll, from Janus Henderson Investors, note that these smaller companies are under-owned, under-researched and lowly valued, and that their extended period of underperformance relative to larger peers should be seen as a pent-up opportunity. With interest rates on a downward path and the UK economy performing better than had been expected, mid- and small-cap company relative performance has begun to improve, and that of HOT as well.

Martyn King

Written by

Martyn King

Director, Financials

Investment Companies

Henderson Opportunities Trust

Taking AIM at the opportunity

Investment trusts
UK all-cap equities

3 October 2024

Price

215p

Market cap

£85m

AUM

£108m

NAV*

239.1p

Discount to NAV

10.1%

*Including income. As at 2 Oct 2024.

Yield

3.3%

Ordinary shares in issue

39.5m

Code/ISIN

HOT/GB0008536574

Primary exchange

LSE

AIC sector

UK All Companies

52-week high/low

236.0p

171.4p

NAV* high/low

260.0p

205.1p

*Including income.

Net gearing*

8%

*As at 31 August 2024.

Fund objective

Henderson Opportunities Trust aims to achieve capital growth in excess of the broad UK stock market from a portfolio of UK investments. Stock selection is not constrained by the benchmark and there are no limits by sector or market capitalisation. Therefore, the portfolio will differ materially from the index.

Bull points

Opportunities across all market segments and market capitalisations.

Disciplined approach to stock selection, valuation and portfolio diversification.

Experienced and stable management team with consistent long-term strategy.

Bear points

Relatively small size means HOT could be overlooked by some investors.

High portfolio weighting in smaller and earlier-stage companies, where liquidity can be thin and returns can be volatile.

Investor appetite for UK smaller companies remains subdued.

Analyst

Martyn King

+44 (0)20 3077 5700

Henderson Opportunities Trust is a research client of Edison Investment Research Limited

With a focus on long-term growth, Henderson Opportunities Trust (HOT) seeks investment opportunities across the breadth of the UK market. This includes a strong bias towards smaller and earlier-stage companies with significant potential to become tomorrow’s leading British businesses. HOT’s managers, James Henderson and Laura Foll, from Janus Henderson Investors, note that these smaller companies are under-owned, under-researched and lowly valued, and that their extended period of underperformance relative to larger peers should be seen as a pent-up opportunity. With interest rates on a downward path and the UK economy performing better than had been expected, mid- and small-cap company relative performance has begun to improve, and that of HOT as well.

Seeking tomorrow’s leaders

Source: Janus Henderson Investors

Smaller companies have begun to outperform

While HOT seeks to balance smaller company volatility with a high level of diversification and a meaningful exposure to growing larger companies, this has not offset the three-year performance drag of smaller company underperformance. However, there are early indications that the tide may be turning, with lowly valued smaller companies likely to benefit more from lower interest rates and a robust UK economy. Since HOT’s FY23 year-end (in October 2023), small- and mid-cap stocks have risen strongly and have outperformed their larger peers. This is reflected in HOT’s performance, even as AIM-listed stocks (c 40% of the portfolio) have continued to lag. In the 11 months to end-September HOT’s NAV total return was 20%, around two percentage points ahead of its broad UK market benchmark, despite September being a noticeably weaker month for the AIM market.

Speculation that inheritance tax (IHT) relief on AIM stocks may be removed in the October UK budget is weighing on the market, although this is far from certain and would run counter to the government’s desire to foster innovation, investment and growth in the UK economy. The managers argue that whatever the outcome, they are invested in well-managed, growing companies, which are not reliant on IHT exemption for their future success, and that this will drive medium-term performance. As we discuss in this note, the managers argue that IHT concerns, having further depressed valuations in an unloved area of the market, should be seen as an opportunity.

Targeting growth with stability

HOT is focused on providing long-term growth, in excess of the broad UK market, with a secondary objective to grow dividends over time. The trust’s all-cap focus gives it the flexibility to seek growth opportunities from across the market, including companies listed on AIM, underpinned by a value-driven style that invests in out-of-favour or under-researched companies. At its core, the HOT portfolio is a blend of what could be tomorrow’s leading British companies, across a wide range of activities and market caps, at different stages of their lifecycle, from promising early-stage businesses to established businesses reinventing themselves.

HOT’s truly all-of-market investment approach is complementary to a wider range of more mainstream offerings, seeking to provide long-term growth, mainly from smaller and mid-sized (SME) companies, while balancing the risks, through a high level of stock diversification (c 90 holdings) and the ‘ballast’ of meaningful exposure to larger, more established businesses. For many investors, this would be difficult to replicate, and HOT’s permanent capital base is ideally suited to the long-term, patient approach required.

Exhibit 1: HOT versus the broad UK equity market by segment

Source: Henderson Opportunities Trust, 30 April 2024. Note: *Other includes unlisted equities.

The trust has been managed consistently for many years by two experienced investment managers, James Henderson (since 2007) and Laura Foll (since 2018) of Janus Henderson Investors (JHI). In turn, they are supported by the broader resources of the JHI equity team.

The investment opportunity

The investment managers believe the recent relative outperformance of SME companies does not reflect their potential, following a period of sustained underperformance. In particular they highlight:

The valuation of UK equities is low in historical and relative terms, and for smaller companies even more so. On a price to sales (P/sales) ratio (our preferred method) smaller companies are trading at the very low end of their range in absolute terms and versus their larger peers. The HOT portfolio P/sales ratio of c 0.6x is well below its 10-year average of over 0.9x.

Exhibit 2: HOT portfolio price to sales ratio

Source: Henderson Opportunities Trust

There are signs that the divergent share price performances of large versus smaller companies may have come to an end. Leaving aside the 2020 recovery from COVID-19 lockdowns, the market trend since around 2016 has seen the very largest companies significantly outperform smaller companies, especially those with more cyclical exposure to the UK economy. There are now increasing signs of a recovery in the absolute and relative performance of mid-cap companies and many smaller companies, although the gains in AIM-listed stocks have continued to lag.

Exhibit 3: Indices’ performance relative to broad market over 10 years

Exhibit 4: Indices’ performance relative to broad market since October 2023

Source: LSEG Data & Analytics. Note: *Numis Smaller Companies Index plus AIM and excluding investment trusts.

Source: LSEG Data & Analytics. Note: *Numis Smaller Companies Index plus AIM and excluding investment trusts.

Exhibit 3: Indices’ performance relative to broad market over 10 years

Source: LSEG Data & Analytics. Note: *Numis Smaller Companies Index plus AIM and excluding investment trusts.

Exhibit 4: Indices’ performance relative to broad market since October 2023

Source: LSEG Data & Analytics. Note: *Numis Smaller Companies Index plus AIM and excluding investment trusts.

Increasing takeover activity underpins valuations. While the valuation opportunity in smaller companies has not yet been widely recognised in the market, low valuations are being increasingly underpinned by takeover activity. For HOT in particular, this included the yet-to-complete cash bids for IDS, owner of Royal Mail, and for the software company IQGeo, both at very significant premiums to the prevailing share prices. The agreed acquisition of IDS is at a 70% premium to the pre-bid price. IQGeo was acquired at a 48% premium to average price over the preceding 12-months and a 19% premium to the price immediately before the bid.

The UK economy is performing better than had been expected. Smaller companies are typically more exposed to the UK economy than larger companies. GDP has recovered well from the short technical recession (two consecutive quarters of negative GDP growth) at the end of 2023. Preliminary data show 0.6% growth in the three months to June following 0.7% in the three months to March. Although the Bank of England expects growth to slow in the second half of the year, growth is overall stronger than many had expected. Market consensus is that interest rates (cut by 25bp to 5.0% in August) will be cut by a further 50bp by year end.

Progressive dividend policy. While HOT is primarily focused on growth, the trust does seek to grow dividends over time. Over the past five years, DPS has increased by an average 11% pa. In FY23, DPS increased 4.4% to 7.1p (35.5p prior to a 5:1 stock split that was effective in March 2024), and aggregate dividends for the first three quarters of FY24 of 4.5p are in line with same period of FY23. HOT’s 3.3% yield is above the average of its peer group.

Performance appears to be turning a corner

We reported on HOT’s outperformance of its benchmark in the six months to 30 April (H124) in our last note, and this has continued since. HOT’s H124 NAV total return was 18.6% compared with 14.2% for the benchmark, while the share price total return was 25.5%. For the 10 months to end-August 2024, HOT’s NAV total return is 28.0% compared with the benchmark 19.7%, and its share price total return is 33.0%. Stock selection has had a positive impact on performance in the current financial year (FY24), including strong performances from larger companies (the banks, Rolls- Royce, Marks & Spencer). Some of the key detractors of performance have been the North Sea oil and gas exploration companies, Serica Energy and Jersey Oil & Gas. On top of an extension of the ‘windfall’ tax, the feared removal of capital allowances in the October budget would be a significant headwind to their operations.

Portfolio positioning by market cap segment has been mixed, with mid-cap stocks and selected smaller companies outperforming but the AIM index lagging.

Exhibit 5: HOT’s performance versus indices to 30 September 2024

Cumulative returns

3m

6m

YTD**

1y

2y

3y

5y

10y

Share price total return

(2.0%)

5.5%

29.0%

17.5%

19.7%

(15.6%)

36.4%

45.0%

NAV total return

0.6%

3.3%

20.3%

9.6%

11.6%

(20.4%)

20.9%

59.3%

Benchmark total return

2.3%

6.1%

18.2%

13.4%

29.1%

23.9%

32.2%

83.6%

NSCIAEX*

3.3%

8.5%

24.2%

15.0%

18.7%

-13.2%

22.9%

65.0%

AIM

(2.7%)

0.6%

11.0%

3.9%

(4.7%)

(37.4%)

(9.1%)

13.4%

Source: LSEG Data & Analytics, Morningstar, Edison Investment Research. Note: *Numis Smaller Companies Index plus AIM and excluding investment trusts. **The 11-month period from the end of the FY23 financial year at 31 October 2023 to 30 September 2024.

The impact of the relative weakness of SME companies, particularly those listed on AIM, still weighs heavily on HOT’s otherwise strong performance record. Although not apparent in standard performance data shown in Exhibit 5, as we showed in our May 2024 review, looking closely at the 10-year period to April 2024 (H124), performance for the first seven years was very strong, compared with an even more significant period of underperformance over the more recent years. During the first seven-year period, HOT’s NAV total return of 97% was more than twice that of the 42% delivered by its benchmark. Smaller companies were outperforming during the period, but HOT’s performance was still well ahead of the Numis Smaller Companies Index including AIM but excluding investment trusts (NSCIAEX)2 return of 76%. Throughout the 10-year period there was no material change in HOT’s strategy and aims, or in the consistent approach applied by the managers, which includes running a diversified portfolio to manage risk. The overriding factor in the underperformance of recent years has been weakness of SME stocks and AIM-listed stocks in particular. Stock selection had a modest positive impact in the period.

  1 The Numis Smaller Companies Index (NSCI) is the main index used as a smaller company benchmark. It targets the bottom 10% of the main UK market by value. The NSCAIEX includes all the constituents of the NSCI and all companies listed on AIM that fall below the NSCI size cut-off.

Exhibit 6: Relative performance changed in 2021

Cumulative total returns

Three years to H124

Seven years to H121

HOT share price

-17.1%

103.2%

HOT NAV

-20.8%

96.8%

Benchmark

17.5%

41.5%

NSCIAEX

-17.9%

75.5%

AIM

-35.2%

70.8%

Source: LSEG Data & Analytics, Edison Investment Research

IHT concerns weigh on AIM in the near term

In our May review, we discussed the relative weakness of the AIM market in recent years but that the market continues to be home for many success stories. Over the past five years, the top performers within the portfolio were all AIM-listed stocks (Ceres Power, IQGeo, Learning Technologies and Vertu Motors).

The inheritance tax break on qualifying AIM shares means that these can be passed on, tax free, if held for at least two years before an individual dies. There is no doubt that it has attracted funds into the AIM market and that its removal would likely create near-term weakness in certain shares or, at the very least, market volatility. A number of investment funds exist specifically to benefit from the inheritance tax breaks on AIM, alongside direct equity investments from founders, families and individual investors. Ironically, if IHT relief were abolished and significant divestments were made, potential share price declines would substantially limit the amount of tax revenue that may otherwise have been expected. More fundamentally, the removal of IHT relief risks reduces access to growth capital for smaller, entrepreneurial companies and undermines the government’s aim to reinvigorate the economy.

Investors have been alert to the potential tax change since the UK general election in July and while the outcome remains uncertain, the AIM market’s performance in recent weeks suggests that some investors have decided to realise profits ahead of the budget whereas others have pulled back from investment. Henderson and Foll note that they are invested in stocks where either the company’s future success or HOT’s long-term performance is not dependent on IHT exemption. They argue that these are good businesses in their own right and that medium-term valuations will be determined by achieving sustainable and growing profits. Where access to capital is an issue, they mostly have strong governance and reporting standards in place that would allow a transition to the main market.

Portfolio positioning

The market cap weightings shown in Exhibit 1 are the output of the investment process rather than a target in themselves. The portfolio managers are focused on long-term returns, with investment decisions driven by a selective, bottom-up approach. They are looking for the best capital growth opportunities, with no specific sector or size remits, and these are most often identified by the managers among smaller companies, particularly those at an early stage.

In monitoring the positioning of the trust, the managers look deeper than the basic distinctions of small, mid and large cap, instead grouping their holdings under one of six classifications or ‘buckets’. The stocks within each of these, with the exception of resources, are expected to generate above-average earnings and capital growth over time. To clarify the process even further, the buckets are grouped under the two broad headings of ‘tomorrow’s leaders’ and ‘stabilisers’. As the name suggests, it is among ‘tomorrow’s leaders’ that the managers expect to see the strongest growth over time. Balancing the expected returns with the risks involved, the managers select a diversified list of companies across all stages of the growth cycle. Tomorrow’s leaders are complemented in the portfolio by investment in stabilisers. These are often larger, mature but still growing businesses, with more predictable cash flows, as well as natural resources companies that provide a hedge against unexpected developments in commodity markets. We provide details of each bucket in our May review.

‘Tomorrow’s leaders’ accounted for 60% of the portfolio at the end of April (H124) when the last full breakdown was published, and the managers have indicated that this has since increased. This is the area in which they see the best opportunities, and where sentiment has been weakest and valuations are more attractive.

Exhibit 7: Portfolio positioning across buckets

Apr-24

Oct-23

Apr-23

Oct-22

Apr-22

Oct-21

H124

FY23

H123

H222

H122

H221

SMID compounders (20–40%)

28%

27%

26%

25%

23%

24%

Growth – small cap (20–40%)

13%

13%

16%

17%

18%

20%

Early stage (0–20%)

6%

6%

7%

7%

10%

13%

Recovery/special situations (0–30%)

13%

16%

14%

10%

11%

11%

Tomorrow’s leaders

60%

62%

63%

59%

62%

68%

Growth – large cap (10–30%)

29%

25%

24%

24%

22%

21%

Natural resources (5–15%)

11%

13%

13%

17%

16%

11%

Stabilisers

40%

38%

37%

41%

38%

32%

Portfolio total

100%

100%

100%

100%

100%

100%

Source: Henderson Opportunities Trust

At the end of August (the last published factsheet), four of the top 10 holdings were AIM stocks, with three banks (Barclays, Standard Chartered and HSBC), Marks & Spencer (in the ‘recovery’ bucket), supermarkets group, Tesco, and miner Rio Tinto accounting for the balance. In aggregate, these 10 holdings accounted for c 26% of the total portfolio, down from c 30% at the end of April (H124). The reduction in the top 10 weighting includes profit taking in strong outperformers such as Barclays and Rolls-Royce, funding the further portfolio migration towards smaller companies including, within the top 10. Rolls Royce was the second largest portfolio holding in April with a weighting of 3.4% but by August this had been reduced to less than 1%. an increased holding in Marshalls. As a measure of the diversification of smaller company holdings, the other 80 holdings were on average 0.9% of the portfolio each.

The AIM stocks within the top 10 holdings may be less well known and are a diverse group, by activity and size (market caps shown are as at the date of publication):

Springfield Properties (market cap: c £125m) is a leading Scottish builder of both private and affordable housing. The company has a strong track record of growth, but its shares significantly de-rated as interest rates rose and the housing market slowed. The company is well positioned for future growth with a sizable land bank.

Boku (market cap: c £475m) is a mobile payments company that allows its customers to charge for their services via an individual’s mobile bill. The company is growing rapidly and is establishing itself globally, with Google, Meta and Amazon among its customer base.

Cohort (market cap: c £370m) provides services to customers in defence, security and related markets. It has been held in the trust for some time but moved into the top 10 holdings as a result of its strong performance. The investment managers remain positive about the company.

Next 15 (market cap: c £450m), is a marketing and PR company with a focus on the faster-growing technology industry. The shares weakened very significantly in September following unexpected news that the contract with its largest customer had not been renewed. The shares have positively contributed to HOT’s performance over the past several years and the managers believe that despite the setback, the current share price is more than justified by the company’s other business, and would particularly benefit from a pick-up in spending activity by its technology customer base.

Exhibit 8: Top 10 holdings

Market segment/index

Main activity

Portfolio weight (%)

Change in weight since (pp)

‘Bucket’

Most recent*

H124

FY23

H124

FY23

Aug-24

Apr-24

Oct-23

Apr-24

Oct-23

Springfield Properties

AIM

House building

3.4

3.1

1.9

0.3

1.5

SMID

Boku

AIM

Mobile payments

2.9

3.0

3.2

-0.1

-0.3

Growth small cap

Standard Chartered

Top 100

Banking

2.8

2.6

2.7

0.2

0.1

Large cap

HSBC

Top 100

Banking

2.7

2.9

2.8

-0.2

-0.1

Large cap

Cohort

AIM

Defence & security technology

2.6

2.2

1.7

0.4

0.9

SMID

Barclays

Top 100

Banking

2.4

4.8

3.6

-2.4

-1.2

Large cap

Marks & Spencer**

Top 100

Clothing, home & food retailer

2.3

2.0

1.9

0.3

0.4

Recovery

Tesco**

Top 100

Food retail

2.2

1.9

2.0

0.3

0.2

Large cap

Rio Tinto

Top 100

Metals & mining

2.2

2.6

2.9

-0.4

-0.7

Natural resources

Next 15

AIM

Marketing and PR

2.1

2.5

2.5

-0.4

-0.4

Growth small cap

Total top 10***

25.6

30.5

29.6

-4.9

-4.0

Source: Henderson Opportunities Trust, Edison Investment Research. Note: *Latest split available, as at 31 August 2024. **Held at 30 April 2024 but not in top 10. ***Actual top 10 weighting at 30 April 2024 and 31 October 2023, and does not equal sum of individual holdings above.

Recent portfolio investments include:

A new position in Entain (a UK 100 stock with a market cap of c £5bn), where the managers believe the valuation does not reflect its exposure to the fast-growing US gambling market. US gaming market deregulation has been a key driver of the strong performance of Flutter Entertainment, also a HOT holding. Flutter is a much larger company with a market cap in excess of £30bn and has been part of the portfolio ‘ballast’ offering both liquidity and growth.

Additions to the existing position in Oxford Nanopore, a genetic sequencing specialist with a market cap of c £1.5bn. The managers considered that the steep de-rating of the shares over the past year fails to take account of the company’s increasing sales diversification, beyond the life science research tools market (where research budgets are under pressure) and towards more applied industrial, clinical and bio-pharma end-uses.

Additions to the position in STV (Scottish version of ITV), with a market cap of c £115m, where the managers consider that the quality of the company’s production business is not reflected in the valuation, while free to air advertising has been recovering this year.

A new position in Sainsbury’s, a UK 100 company with a market cap of almost £7bn, which has re-set its price competitiveness relative to the discounters and is back winning market share, at a reasonable valuation with an attractive yield.

The portfolio positioning by sector is also a by-product of stock selection rather than a target. The significant overweighting to industrials reflects the investment managers’ assessment of the upside potential of more domestically focused, cyclical businesses where the valuations fail to capture the longer-term potential from operational gearing and re-rating. The recent reduction in the industrials weighting primarily reflects the profit-taking in Rolls Royce while the increase in the consumer discretionary weighting includes the investment in Entain as well strong performances from existing holdings such as Flutter and Gym Group.

Exhibit 9: Portfolio sector weightings (%)

Most recent

H124

FY23

Index weight

Active weight

Change in portfolio weight since:

Aug-24

Apr-24

Oct-23

Aug-24

Aug-24

Apr-24

Oct-23

Industrials

26.2

29.4

26.6

12.1

14.1

-3.2

-0.4

Financials

19.4

20.5

20.6

24.5

-5.1

-1.1

-1.2

Consumer discretionary

17.3

14.7

19.0

11.0

6.3

2.6

-1.7

Technology

9.1

8.4

8.6

1.3

7.8

0.7

0.5

Energy

6.8

8.3

9.2

10.2

-3.4

-1.5

-2.4

Basic materials

5.8

6.6

6.9

6.3

-0.5

-0.8

-1.1

Healthcare

5.2

4.3

4.9

12.7

-7.5

0.9

0.3

Consumer staples

5.5

3.9

2.0

14.4

-8.9

1.6

3.5

Telecommunications

1.2

0.8

1.1

1.2

0.0

0.4

0.1

Real estate

3.5

3.1

1.2

2.6

0.9

0.4

2.3

Utilities

0.0

0.0

0.0

3.8

-3.8

0.0

0.0

Total

100.0

100.0

100.0

100.0

Source: Henderson Opportunities Trust, Edison Investment Research

Peer group comparison

HOT is a member of the AIC’s UK All Companies sector, comprising seven member trusts of which HOT is the smallest. Despite HOT’s modest size, its ongoing charges are in line with the group average, and despite its focus on capital growth, dividend growth has been strong and HOT provides the second highest yield in the sector.

Among the sector constituents, there is undoubtedly overlap between investment strategies, although HOT is the only trust that is truly UK and truly all-cap.3

  2 Schroder UK Mid Cap is a mid-cap specialist, while Mercantile invests in small- and mid-cap companies. Aurora, with a concentrated portfolio of 15–20 stocks, and Baillie Gifford UK Growth Trust both have a mid-cap bias (c 50% or over), while Artemis Alpha Trust and Fidelity Special Values both have significant (c 20–30%) non-UK holdings.

For the reasons discussed above, HOT’s exposure to smaller companies, and AIM-listed stocks in particular, has significantly affected its short-term performance versus this diverse peer group and this has fed through to the long-term performance data. The trust’s discount to NAV is nonetheless broadly in line with the simple average of the peer group.

Exhibit 10: Selected peer group*

% unless stated

Market cap £m

NAV TR
1 year

NAV TR
3 year

NAV TR
5 year

NAV TR
10 year

Ongoing
charge

Perf.
fee

Discount
(cum-fair)

Net
gearing

Dividend
yield

Henderson Opportunities Trust

84.9

8.5

(20.3)

19.2

59.2

1.0

No

(9.6)

107

3.3

Artemis Alpha Trust

128.2

27.5

0.5

31.8

46.3

1.1

No

(7.4)

97

1.7

Aurora

187.6

19.2

23.9

50.5

85.8

2.0

Yes

(10.9)

88

1.4

Baillie Gifford UK Growth Trust

252.6

17.2

(6.9)

17.6

51.4

0.7

No

(14.3)

108

3.2

Fidelity Special Values

1,009.6

17.7

25.0

50.4

131.8

0.7

No

(8.1)

109

2.8

Mercantile

1,844.0

21.0

0.8

34.1

119.9

0.5

No

(11.0)

117

3.2

Schroder UK Mid Cap

211.6

16.6

(3.4)

25.9

86.6

1.0

No

(11.9)

112

3.3

Simple average

531.2

18.2

2.8

32.8

83.0

1.0

-

(10.5)

105

2.7

HOT rank in peer group

7

7

7

6

5

3

-

3

5

2

Source: Morningstar, Edison Investment Research. Note: *Performance as at 2 October 2024 based on cum-fair NAV. TR, total return. Net gearing is total assets less cash and equivalents as a percentage of net assets (100 = ungeared).


General disclaimer and copyright

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Accuracy of content: All information used in the publication of this report has been compiled from publicly available sources that are believed to be reliable, however we do not guarantee the accuracy or completeness of this report and have not sought for this information to be independently verified. Opinions contained in this report represent those of the research department of Edison at the time of publication. Forward-looking information or statements in this report contain information that is based on assumptions, forecasts of future results, estimates of amounts not yet determinable, and therefore involve known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of their subject matter to be materially different from current expectations.

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No personalised advice: The information that we provide should not be construed in any manner whatsoever as, personalised advice. Also, the information provided by us should not be construed by any subscriber or prospective subscriber as Edison’s solicitation to effect, or attempt to effect, any transaction in a security. The securities described in the report may not be eligible for sale in all jurisdictions or to certain categories of investors.

Investment in securities mentioned: Edison has a restrictive policy relating to personal dealing and conflicts of interest. Edison Group does not conduct any investment business and, accordingly, does not itself hold any positions in the securities mentioned in this report. However, the respective directors, officers, employees and contractors of Edison may have a position in any or related securities mentioned in this report, subject to Edison's policies on personal dealing and conflicts of interest.

Copyright: Copyright 2024 Edison Investment Research Limited (Edison).

Australia

Edison Investment Research Pty Ltd (Edison AU) is the Australian subsidiary of Edison. Edison AU is a Corporate Authorised Representative (1252501) of Crown Wealth Group Pty Ltd who holds an Australian Financial Services Licence (Number: 494274). This research is issued in Australia by Edison AU and any access to it, is intended only for "wholesale clients" within the meaning of the Corporations Act 2001 of Australia. Any advice given by Edison AU is general advice only and does not take into account your personal circumstances, needs or objectives. You should, before acting on this advice, consider the appropriateness of the advice, having regard to your objectives, financial situation and needs. If our advice relates to the acquisition, or possible acquisition, of a particular financial product you should read any relevant Product Disclosure Statement or like instrument.

New Zealand

The research in this document is intended for New Zealand resident professional financial advisers or brokers (for use in their roles as financial advisers or brokers) and habitual investors who are “wholesale clients” for the purpose of the Financial Advisers Act 2008 (FAA) (as described in sections 5(c) (1)(a), (b) and (c) of the FAA). This is not a solicitation or inducement to buy, sell, subscribe, or underwrite any securities mentioned or in the topic of this document. For the purpose of the FAA, the content of this report is of a general nature, is intended as a source of general information only and is not intended to constitute a recommendation or opinion in relation to acquiring or disposing (including refraining from acquiring or disposing) of securities. The distribution of this document is not a “personalised service” and, to the extent that it contains any financial advice, is intended only as a “class service” provided by Edison within the meaning of the FAA (i.e. without taking into account the particular financial situation or goals of any person). As such, it should not be relied upon in making an investment decision.

United Kingdom

This document is prepared and provided by Edison for information purposes only and should not be construed as an offer or solicitation for investment in any securities mentioned or in the topic of this document. A marketing communication under FCA Rules, this document has not been prepared in accordance with the legal requirements designed to promote the independence of investment research and is not subject to any prohibition on dealing ahead of the dissemination of investment research.

This Communication is being distributed in the United Kingdom and is directed only at (i) persons having professional experience in matters relating to investments, i.e. investment professionals within the meaning of Article 19(5) of the Financial Services and Markets Act 2000 (Financial Promotion) Order 2005, as amended (the "FPO") (ii) high net-worth companies, unincorporated associations or other bodies within the meaning of Article 49 of the FPO and (iii) persons to whom it is otherwise lawful to distribute it. The investment or investment activity to which this document relates is available only to such persons. It is not intended that this document be distributed or passed on, directly or indirectly, to any other class of persons and in any event and under no circumstances should persons of any other description rely on or act upon the contents of this document.

This Communication is being supplied to you solely for your information and may not be reproduced by, further distributed to or published in whole or in part by, any other person.

United States

Edison relies upon the "publishers' exclusion" from the definition of investment adviser under Section 202(a)(11) of the Investment Advisers Act of 1940 and corresponding state securities laws. This report is a bona fide publication of general and regular circulation offering impersonal investment-related advice, not tailored to a specific investment portfolio or the needs of current and/or prospective subscribers. As such, Edison does not offer or provide personal advice and the research provided is for informational purposes only. No mention of a particular security in this report constitutes a recommendation to buy, sell or hold that or any security, or that any particular security, portfolio of securities, transaction or investment strategy is suitable for any specific person.

London │ New York │ Frankfurt

20 Red Lion Street

London, WC1R 4PS

United Kingdom

London │ New York │ Frankfurt

20 Red Lion Street

London, WC1R 4PS

United Kingdom

General disclaimer and copyright

This report has been commissioned by Henderson Opportunities Trust and prepared and issued by Edison, in consideration of a fee payable by Henderson Opportunities Trust. Edison Investment Research standard fees are £60,000 pa for the production and broad dissemination of a detailed note (Outlook) following by regular (typically quarterly) update notes. Fees are paid upfront in cash without recourse. Edison may seek additional fees for the provision of roadshows and related IR services for the client but does not get remunerated for any investment banking services. We never take payment in stock, options or warrants for any of our services.

Accuracy of content: All information used in the publication of this report has been compiled from publicly available sources that are believed to be reliable, however we do not guarantee the accuracy or completeness of this report and have not sought for this information to be independently verified. Opinions contained in this report represent those of the research department of Edison at the time of publication. Forward-looking information or statements in this report contain information that is based on assumptions, forecasts of future results, estimates of amounts not yet determinable, and therefore involve known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of their subject matter to be materially different from current expectations.

Exclusion of Liability: To the fullest extent allowed by law, Edison shall not be liable for any direct, indirect or consequential losses, loss of profits, damages, costs or expenses incurred or suffered by you arising out or in connection with the access to, use of or reliance on any information contained on this note.

No personalised advice: The information that we provide should not be construed in any manner whatsoever as, personalised advice. Also, the information provided by us should not be construed by any subscriber or prospective subscriber as Edison’s solicitation to effect, or attempt to effect, any transaction in a security. The securities described in the report may not be eligible for sale in all jurisdictions or to certain categories of investors.

Investment in securities mentioned: Edison has a restrictive policy relating to personal dealing and conflicts of interest. Edison Group does not conduct any investment business and, accordingly, does not itself hold any positions in the securities mentioned in this report. However, the respective directors, officers, employees and contractors of Edison may have a position in any or related securities mentioned in this report, subject to Edison's policies on personal dealing and conflicts of interest.

Copyright: Copyright 2024 Edison Investment Research Limited (Edison).

Australia

Edison Investment Research Pty Ltd (Edison AU) is the Australian subsidiary of Edison. Edison AU is a Corporate Authorised Representative (1252501) of Crown Wealth Group Pty Ltd who holds an Australian Financial Services Licence (Number: 494274). This research is issued in Australia by Edison AU and any access to it, is intended only for "wholesale clients" within the meaning of the Corporations Act 2001 of Australia. Any advice given by Edison AU is general advice only and does not take into account your personal circumstances, needs or objectives. You should, before acting on this advice, consider the appropriateness of the advice, having regard to your objectives, financial situation and needs. If our advice relates to the acquisition, or possible acquisition, of a particular financial product you should read any relevant Product Disclosure Statement or like instrument.

New Zealand

The research in this document is intended for New Zealand resident professional financial advisers or brokers (for use in their roles as financial advisers or brokers) and habitual investors who are “wholesale clients” for the purpose of the Financial Advisers Act 2008 (FAA) (as described in sections 5(c) (1)(a), (b) and (c) of the FAA). This is not a solicitation or inducement to buy, sell, subscribe, or underwrite any securities mentioned or in the topic of this document. For the purpose of the FAA, the content of this report is of a general nature, is intended as a source of general information only and is not intended to constitute a recommendation or opinion in relation to acquiring or disposing (including refraining from acquiring or disposing) of securities. The distribution of this document is not a “personalised service” and, to the extent that it contains any financial advice, is intended only as a “class service” provided by Edison within the meaning of the FAA (i.e. without taking into account the particular financial situation or goals of any person). As such, it should not be relied upon in making an investment decision.

United Kingdom

This document is prepared and provided by Edison for information purposes only and should not be construed as an offer or solicitation for investment in any securities mentioned or in the topic of this document. A marketing communication under FCA Rules, this document has not been prepared in accordance with the legal requirements designed to promote the independence of investment research and is not subject to any prohibition on dealing ahead of the dissemination of investment research.

This Communication is being distributed in the United Kingdom and is directed only at (i) persons having professional experience in matters relating to investments, i.e. investment professionals within the meaning of Article 19(5) of the Financial Services and Markets Act 2000 (Financial Promotion) Order 2005, as amended (the "FPO") (ii) high net-worth companies, unincorporated associations or other bodies within the meaning of Article 49 of the FPO and (iii) persons to whom it is otherwise lawful to distribute it. The investment or investment activity to which this document relates is available only to such persons. It is not intended that this document be distributed or passed on, directly or indirectly, to any other class of persons and in any event and under no circumstances should persons of any other description rely on or act upon the contents of this document.

This Communication is being supplied to you solely for your information and may not be reproduced by, further distributed to or published in whole or in part by, any other person.

United States

Edison relies upon the "publishers' exclusion" from the definition of investment adviser under Section 202(a)(11) of the Investment Advisers Act of 1940 and corresponding state securities laws. This report is a bona fide publication of general and regular circulation offering impersonal investment-related advice, not tailored to a specific investment portfolio or the needs of current and/or prospective subscribers. As such, Edison does not offer or provide personal advice and the research provided is for informational purposes only. No mention of a particular security in this report constitutes a recommendation to buy, sell or hold that or any security, or that any particular security, portfolio of securities, transaction or investment strategy is suitable for any specific person.

London │ New York │ Frankfurt

20 Red Lion Street

London, WC1R 4PS

United Kingdom

London │ New York │ Frankfurt

20 Red Lion Street

London, WC1R 4PS

United Kingdom

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IRLAB Therapeutics has announced an encouraging update for the ongoing Phase I trial for IRL757, which is being developed as a potential treatment for apathy. The single ascending dose (SAD) portion of the study has been successfully completed, with the initial data showing good absorption and exposure in the body, as well as a desirable safety and tolerability profile. The next step will be the multiple ascending dose (MAD) portion of the study, which management notes should be completed by end-2024. We view the update as a positive sign that the trial is progressing as planned, and believe that the top-line results (expected in Q125) could represent an important catalyst for IRLAB.

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